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Liposomes for Targeted Delivery of Active Agents against Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease)

机译：靶向递送抗神经退行性疾病（阿尔茨海默氏病和帕金森氏病）活性剂的脂质体

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摘要

Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease represent a huge unmet medical need. The prevalence of both diseases is increasing, but the efficacy of treatment is still very limited due to various factors including the blood brain barrier (BBB). Drug delivery to the brain remains the major challenge for the treatment of all neurodegenerative diseases because of the numerous protective barriers surrounding the central nervous system. New therapeutic drugs that cross the BBB are critically needed for treatment of many brain diseases. One of the significant factors on neurotherapeutics is the constraint of the blood brain barrier and the drug release kinetics that cause peripheral serious side effects. Contrary to common belief, neurodegenerative and neurological diseases may be multisystemic in nature, and this presents numerous difficulties for their potential treatment. Overall, the aim of this paper is to summarize the last findings and news related to liposome technology in the treatment of neurodegenerative diseases and demonstrate the potential of this technology for the development of novel therapeutics and the possible applications of liposomes in the two most widespread neurodegenerative diseases, Alzheimer's disease and Parkinson's disease.
机译：神经退行性疾病，例如阿尔茨海默氏病和帕金森氏病，代表了巨大的医疗需求。两种疾病的患病率都在增加，但是由于包括血脑屏障（BBB）在内的各种因素，治疗的效果仍然非常有限。由于围绕中枢神经系统的众多保护性屏障，将药物输送到大脑仍然是治疗所有神经退行性疾病的主要挑战。穿越BBB的新治疗药物对于治疗许多脑部疾病至关重要。神经治疗的重要因素之一是血脑屏障的限制和引起周围严重副作用的药物释放动力学。与普遍的看法相反，神经退行性疾病和神经系统疾病本质上可能是多系统性的，这给它们的潜在治疗带来了许多困难。总体而言，本文的目的是总结与脂质体技术有关的神经退行性疾病治疗的最新发现和新闻，并展示该技术在新型疗法的发展中的潜力以及脂质体在两种最广泛的神经退行性疾病中的可能应用疾病，阿尔茨海默氏病和帕金森氏病。

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    Spuch, Carlos; Navarro, Carmen;

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  • 年度 2011
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  • 原文格式 PDF
  • 正文语种 {"code":"en","name":"English","id":9}
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